micrornas: critical regulators of mrna traffic and translational control with promising biotech and therapeutic applications

نویسندگان

sahar ansari basir

khosrow adeli

چکیده

context:micrornas (mirnas) are a class of short, endogenously-initiated, non-coding rnas that post-transcriptionally control gene expression via translational repression or mrna turnover. mirnas have attracted much attention in recent years as they play critical roles in gene expression and are promising tools with many biotech and therapeutic applications. the molecular mechanisms underlying the translational control of mrnas are not fully understood but emerging evidence point to a key role for micrornas in this process. evidence acquisition:in this review, we discuss the potential role of mirnas as regulators of mrna traffic and translational control, focusing on molecular mechanisms of mirna-mediated control of eukaryotic mrna stability and translational efficiency. results:translational control by mirnas is often associated with silencing and repression of mrnas via accumulation within cytoplasmic processing bodies (p-bodies), the site of mrna storage and/or decay. specific mirnas can interact with the 3’utr or 5’utr of target mrnas and regulate their stability as well as translational efficiency. a better understanding of these mechanisms is critical in advancing our knowledge of the role of these regulatory rnas in modulating protein synthesis and controlling metabolic pathways in health and disease. conclusions:the discovery of mirnas and their important role in controlling many aspects of cell function and metabolism have led to considerable interest in biotech applications of mirnas and their application in modulating specific gene expression. we thus highlight the growing biotech and therapeutic applications of mirnas.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

MicroRNAs: Critical Regulators of mRNA Traffic and Translational Control with Promising Biotech and Therapeutic Applications

Context:MicroRNAs (miRNAs) are a class of short, endogenously-initiated, non-coding RNAs that post-transcriptionally control gene expression via translational repression or mRNA turnover. MiRNAs have attracted much attention in recent years as they play critical roles in gene expression and are promising tools with many biotech and therapeutic applications. The molecular mechanisms und...

متن کامل

Production and quality control of 166Ho-Chitosan for therapeutic applications

Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...

متن کامل

a comparison of teachers and supervisors, with respect to teacher efficacy and reflection

supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...

15 صفحه اول

MicroRNAs as Immune Regulators of Inflammation in Children with Epilepsy

Epilepsy is a chronic clinical syndrome of brain function which is caused by abnormal discharge of neurons. MicroRNAs (MiRNAs) are small noncoding RNAs which act post transcriptionally to regulate negatively protein levels. They affect neuroinflammatory signaling, glial and neuronal structure and function, neurogenesis, cell death, and other processes linked to epileptogenesis. The aim of this ...

متن کامل

on the relationship between critical thinking, metacognition and translation quality of literary and economic texts

این مطالعه سعی دارد تا رابطه تفکر انتقادی و مهارت های شناختی را به عنوان دو عنصر مهم روانشناسی شناختی با کیفیت ترجمه متون ادبی و اقتصادی بررسی کند. صد دانشجوی سال آخر ترجمه که در مقطع کارشناسی مشغول به تحصیل هستند برای شرکت در این مطالعه انتخاب شدند و آزمون های تافل تفکر انتقادی و مهارت های شناختی از آنها گرفته شد. آزمون ترجمه ادبی و اقتصادی نیز برای تعیین سطح کیفیت ترجمه گرفته شد. یافته های حا...

the relationship between locus of control, efl reading and writing achievement, and use of language learning strategies

تاثیر منبع کنترل رفتار بر روی موفقیت تحصیلی زبان آموزان انگلیسی بندرت در ایران ارزیابی شده است. هدف این تحقیق ارزیابی رابطه بین منبع کنترل رفتار زبان آموزان انگلیسی و موفقیت آنها در مهارت های خواندن و نوشتن زبان انگلیسی است. محقق همچنین رابطه بین منبع کنترل رفتار و راهبردهای یادگیری زبان انگلیسی را در این تحقیق جستجو می کند. بدین منظور محقق ابتدا نسخه فارسی پرسشنامه منبع کنترل رفتار (duttweiler...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of biotechnology

ناشر: national institute of genetic engineering and biotechnology

ISSN 1728-3043

دوره 11

شماره 3 2013

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023